SMTL Dressings Datacard



Product Name: Oxyzyme
Classification Name: Hydrogel dressing, oxygen and iodine releasing
Manufacturer: Insense

Description

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Oxyzyme is a hydrogel dressing which, in common with other hydrogel sheet products, provides a moist environment that promotes autolytic wound debridement, reduces pain, and facilitates healing.

Uniquely, however, Oxyzyme also incorporates a biochemical system which increases the concentration of dissolved oxygen at the wound surface and liberates iodine from low levels (less than 0.04% w/w) of iodide ions present within the gel matrix.

Oxyzyme consists of two separate components which must be applied together as directed in order to activate the biochemical process.

The two gel sheets are presented in individual aluminium foil laminate pouches with easy peel tabs, sealed in one plastic outer peelable pouch.

The first component, which is placed directly upon the wound surface, consists of a simple hydrogel sheet containing glucose. The second component is a smaller sheet of gel containing glucose oxidase, a naturally occurring enzyme which, in the presence of oxygen, catalyzes the oxidation of (beta)-D-glucose to D-gluconic acid and hydrogen peroxide.

When the two gels are brought together, the glucose in the lower sheet diffuses into the other upper one. The hydrogen peroxide that is formed is released back into the gel and diffuses through the dressing, oxidizing any iodide ions it encounters to free iodine and liberating oxygen which remains in solution. Any peroxide that reaches the wound surface is immediately broken down to water and oxygen.

The iodine it thought to exert a beneficial antimicrobial effect within the gel and also help to prevent the proliferation of microorganisms at the wound-dressing interface, whilst the dissolved oxygen is believed to have beneficial effects upon different aspects of cellular activity within the wound.

The dressing therefore acts a little like a molecular pump, transporting dissolved oxygen through the dressing from the external environment and delivering it to the wound surface.

Indications

Oxyzyme is indicated for the treatment of non-infected dry or lightly exuding chronic wounds. Although the iodine contained within the hydrogel imparts some protection against the growth of microorganisms, Oxyzyme is not indicated as a primary treatment for overtly infected wounds but it may be used in conjunction with systemic antimicrobial therapy where clinically indicated.

Contra-indications

Because Oxyzyme contains low levels of iodine it should not be used on patients with a known or suspected sensitivity or allergy to iodine, or patients with a thyroid disorder such as Hashimoto's thyroiditis or non-toxic nodular goitre. It should also not be used any individuals who are sensitive to, or have had an allergic reaction to, any of its components.

Oxyzyme should be used with caution on pregnant or lactating mothers.

Method of use

The dressing is applied in two stages. Initially the larger hydrogel sheet is removed from Pack 1 and the release liners are removed from one side. The gel sheet is then placed centrally over the wound, ensuring that the dressing is not creased or folded. The release liners on the outer surface of the gel sheet are then removed.

At this stage the contents of Pack 2 are removed and the release papers peeled away from one side of this, the smaller hydrogel sheet. This second hydrogel layer is then placed directly in contact with the first hydrogel ensuring that it is located squarely in the centre, directly over the wound. It is important to ensure that the dressing is not creased or folded and that there is minimal trapped air between the two gel surfaces to facilitate intimate contact between the two layers. The outer release liners are then removed.

The dressing is completed by the application of a semipermeable film or foam sheet (not supplied), held in place by a suitable bandage or bandaging system as appropriate.

Frequency of Change

The frequency of dressing change is determined principally by the condition of the wound but is typically every 2-3 days.

Warnings

Contact allergy and local oedema have been reported in rare cases. Minor reddening or swelling around the wound may occur without necessarily being an allergic reaction.

If these or any other symptoms or signs of infection develop (increased pain or marked unexpected changes in wound colour or appearance), the dressing should be discontinued and a clinical opinion sought.

Presentation

The dressing comprises two sterile components in individual aluminium foil laminate pouches with easy peel tabs sealed in a plastic outer peelable pouch.

Storage

The dressing should be stored at room temperature (below 25ºc)

Sizes

The sterilised dressing is supplied in a 10 cm x 10 cm format.

Bibliography

Ivins N, Simmonds W, Turner A, Harding K. The use of an oxygenating hydrogel dressing in VLU. Wounds UK 2007; 3(1).

Queen D, Coutts P, Fierheller M, Sibbald G. The use of a novel oxygenating hydrogel dressing in the treatment of different chronic wounds, Advances in Skin & Wound Care April 2007; 20(4):200-207.

Availability

Further information on Insense and their wound healing division, Archimed, is available on the Insense web site.


Revision Details

Revision AuthorDr S. Thomas
Revision No 1.2
Revision date2007/07/06

This datacard has been prepared from data provided by the manufacturer and/or from published literature.



All materials copyright © 1992-2007 by the Surgical Materials Testing Lab. unless otherwise stated.

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Last Modified: Tuesday, 07-Jan-2014 16:12:49 GMT